Biomimetic tissue engineering of vascular systems.

Set the right pulse for your cells.

To assure the formation of a biomimetic blood vessel structure our system creates the right biomechanical environment to trigger self-organisation of the cells in 3D. Shear stress induced by flow causes endothelial cells to concentrate on the inner surface of the blood vessel model and form a confluent layer. Whereas smooth muscle cells detect periodic changes of tension associated with a pulsatile pressure profile, which leads to a tangential orientation of the cells around the blood vessel.